Modulating FOXO3 transcriptional activity by small, DBD-binding molecules
نویسندگان
چکیده
منابع مشابه
Methylation by Set9 modulates FoxO3 stability and transcriptional activity
The FoxO family of transcription factors plays an important role in longevity and tumor suppression by regulating the expression of a wide range of target genes. FoxO3 has recently been found to be associated with extreme longevity in humans and to regulate the homeostasis of adult stem cell pools in mammals, which may contribute to longevity. The activity of FoxO3 is controlled by a variety of...
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ژورنال
عنوان ژورنال: eLife
سال: 2019
ISSN: 2050-084X
DOI: 10.7554/elife.48876